Living with this pandemic time where we are all dealing with COVID-19, everyone worries mainly about the treatment options available in taking care of the virus. Unfortunately, we don’t have any access to the possible drug that can prevent or cure the disease. Though some countries claim to have found the effective drug, these are not approved and not recommended by the Food and Drug Administration (FDA).
But since it is our human nature to be curious, we want to try and work on something instead of wasting time waiting. That explains why some licensed physicians consider using certain drugs to treat COVID-19 patients. Honestly, these experts cannot wholeheartedly say that the drugs they recommend are the ones necessary for the specific purpose of getting rid of Coronavirus. But with regards to results, most of these drugs show a potential advantage.
Remdesivir – It is a drug that has a wide range of antiviral activity that slow down viral replication. Meaning, it is a drug that helps in the premature termination of RNA transcription. It also has in-vivo and in-vitro activity against related Coronavirus diseases. Honestly, it is a drug that is still under trial but is proven to have retroactivity against certain conditions such as severe acute respiratory syndrome or SARS. Remdesivir contains the necessary chemicals that can help the respiratory system. It went in progress to an evaluation to check the efficacy of the drug for moderate and severe COVID-19 cases. Unfortunately, despite its promising capabilities, its clinical stand is not well-understood.
Tocilizumab – It is a drug that is most widely used by clinicians that are given through the form of injection. Tocilizumab contains IL-6 receptors responsible for reducing cytokine and acute reactants that are beneficial for fighting Coronavirus infection. Though many clinicians are now engaged in providing the Tocilizumab shots to the patients with mild and severe cases of COVID-19, it is still under investigation. Fortunately, it reached a phase 2 clinical trial so that it can be a promising sign. But then again, it is too early to conclude that this drug holds the future since there is possible drug dependency.
Chloroquine/ Hydroxychloroquine – These are oral prescription drugs that are used for treating malaria and other certain inflammatory conditions. Both of the drugs have an in-vitro and in-vivo activity against SARS Co-1 and SARS Co-2, the COVID-19. The use of Chloroquine associates with a decreased duration of the virus’s symptoms. It is entirely promising since the CNHC or China National Health Commission already included it in their drug and treatment guidelines. Hydroxychloroquine, which contains a relatively high potency in treating COVID-19 compared to Chloroquine, reaches more clinical attention. However, there is no published supporting data that can back up this claim. If in case there are some, those are pretty limited.
Lopinavir/ Ritonavir – These two types of drugs appear to have little to no role in the treatment of Coronavirus infection. However, the combined Proteus inhibitor, which is primarily used for treating HIV infections, has in-vitro activity against SARS. Thus, it becomes the reason to consider Lopinavir/ Ritonavir to be included in the possible drugs for COVID-19. But most clinicians do want to consider it as practical use for hospitalized patients with severe Coronavirus cases. Unfortunately, the setting is unclear as of date because there is no clinical improvement. Aside from that, these drugs do not show promise in the recent scientific trial in China, where they test recent pneumonia cases in a limited number of patients.
All these drugs may show valuable results. But it is important to note that you can’t take it directly from the counter.